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KMID : 0358419920350101483
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Korean Journal of Obstetrics and Gynecology
1992 Volume.35 No. 10 p.1483 ~ p.1488
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The Effect of Antenatal Dexamethasone Administration on the Prevention of RDS in Preterm Delivery
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조재성/Cho JS
이윤태/박용원/남궁란/송찬호/Lee YT/Park YW/Namkung R/Song CH
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Abstract
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A clinical study was carried out to establish whether the antenatal administration of dexamethasone results in improved neonatal outcome in premature delivery and to determine whether there is increased risk of neonatal and maternal infection. In this study, the outcome of 24 infants who received prenatal dexamethasome therapy was compared retrospectively to that of 25 infants delivered to untreated women who have preterm delivery during 28∼34 weeks` gestation. The incidence of respiratory distress syndrome (RDS) in steroid-treated infants was 25%(6/24) compared with 36%(9/25) in untreated infants and was not significantly different (p=0.3). The incidence of RDS according to mode of delivery was 20% in infnats delivered vaginally and 37.9% in infants underwent cesarean section. There was increased incidence of maternal and fetal morbidity in the steroid-treated gorup, especially fetal morbidity (sepsis, DIC, meningitis, omphalitis etc) (p<0.01). We concluded taht antenatal dexamethasone therapy in preterm pregnancies may decrease the incidence of RDS and increase neonatal morbidity significantly.
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KEYWORD
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